These findings in the macaque monkey provide strong predictions of differential functional connectivity in the human brain that are testable using RSFC data. We hypothesized that I BET 762 the patterns of functional connectivity between areas 6, 44 and 45 and posterior temporal and parietal regions in the human brain would exhibit a degree of specificity similar to that established for connections between the homologues of these areas in the macaque monkey, using the autoradiographic method. To test this hypothesis, we performed

an a-priori seed-based functional connectivity analysis of human resting state data, in which the precise placement of seed regions of interest in areas 6, 44 and 45 was determined on an individual basis according to sulcal

and gyral morphology. We then verified the observed distinctions between the patterns of RSFC exhibited by these regions by performing a data-driven spectral clustering analysis, in which we partitioned the inferior frontal ROI into groups of voxels exhibiting similar patterns of RSFC. The results of these two analyses were consistent with one another, and with the predictions from the experimental anatomical tracing studies in the macaque monkey. These findings indicate that the perisylvian parietal and temporal functional connectivity with Reverse transcriptase left ventrolateral frontal cortex in the PF-562271 cost human brain maintains the same basic patterns observed in non-human primates. These patterns of connectivity are schematically summarized in Fig. 6. The present RSFC analyses demonstrated a striking dissociation

between the pattern of RSFC associated with the ventral part of area 6 that is involved in orofacial control and the patterns of RSFC associated with the two areas that comprise Broca’s region (areas 44 and 45). The RSFC profile of BA 6 was that of a motor zone – it exhibited functional connectivity with dorsal premotor cortex, the primary motor and somatosensory cortex within and around the central sulcus, the secondary somatosensory areas in the upper bank of the Sylvian fissure and, on the medial surface of the brain, the supplementary motor area and the cingulate motor areas. This pattern of RSFC (which is consistent with the known anatomical connectivity of ventral premotor area 6 established in monkey anatomical tracing studies) was not shared with areas 44 and 45. Of particular interest was the RSFC of ventral area 6 with the supramarginal gyrus. In the macaque monkey, ventral area 6 exhibits strong cortico-cortical connections only with the most anterior part of the inferior parietal lobule (referred to as area PF) (Petrides & Pandya, 1984, 2009; Matelli et al.