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collection and PCR- RFLP analysis. ZZ, HX and XZ participated in statistical analysis and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Malignant tumor growth, progression, and metastasis depend on adequate blood supply [1]. Much attention has been focused on angiogenesis which is known as the sprouting DOCK10 of new vessels from existing microvessels. The traditional anticancer treatment is targeting the vascular and endothelial cells [2, 3]. In 1999, Maniotis and co-workers introduced the concept of vasculogenic mimicry (VM), a new mechanism by which aggressive melanoma may acquire a blood supply [4]. VM channels are patterned networks of interconnected loops of periodic acid-Schiff (PAS)-positive extracellular matrix forming by aggressive melanoma tumor cells instead of endothelial cells. Moreover, it is correlated with poor prognosis in patients with tumors [4] and has been described in several other aggressive tumor types [5–8]. Uveal melanoma, the most common primary intra-ocular tumor in adults, has been widely concerned as the purely hematogenous [9]. Nearly 50% of uveal melanoma patients die from metastatic melanoma [10].