Langmuir 2001, 17:1406–1410 CrossRef 33 Gou L, Murphy CJ: Soluti

Langmuir 2001, 17:1406–1410.check details CrossRef 33. Gou L, Murphy CJ: Solution-phase synthesis of Cu 2 O nanocubes. Nano Lett 2003, 3:231–234.CrossRef 34. Chang Y, Teo JJ, Zeng HC: Formation of colloidal CuO nanocrystallites and their spherical aggregation and reductive transformation to hollow Cu 2 O nanospheres. Langmuir

2005, 21:1074–1079.CrossRef 35. Kang H, Lee HJ, Park JC, Song H, Park KH: Solvent-free microwave promoted [3 + 2] cycloaddition of alkyne-azide in uniform CuO hollow nanospheres. Top Catal 2010, 53:523–528.CrossRef 36. Park JC, Kim J, Kwon H, Song H: Gram-scale synthesis of Cu 2 O nanocubes and subsequent oxidation to CuO hollow nanostructures Defactinib for lithium-ion battery anode materials. Adv Mater 2009, 21:803–807.CrossRef 37. Wu CK, Yin M, O’Brien S, Koberstein JT: Quantitative analysis of copper oxide nanoparticle composition and structure by X-ray photoelectron spectroscopy. Chem Mater 2006, 18:6054–6058.CrossRef 38. Sperotto E, van Klink GPM, van Koten G, de Vries JG: The mechanism of the modified Ullmann reaction. Dalton Trans 2010, 39:10338–10351.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions The manuscript was written through the contributions of all authors (HW, MB, EH, JCP, HS, and KHP). All authors read and approved the final manuscript.”
“Background

Nanomaterials and nanoparticles have recently received EZH1/2 inhibitor considerable attention because of their unique properties and diverse applications in biotechnology and life science. Nanosilver products, which have well-known antimicrobial properties, have been used extensively in a range of medical settings [1–5]. Bactericidal properties of silver in the form of ions, nanoparticles, or composite nanodevices based on thin Ag films have been broadly reported [6, 7]. Antibacterial properties, however, are one, but not the only prerequisites for successful integration of functional artificial materials into living tissues. Biocompatibility and side cytotoxicity of such materials

Mannose-binding protein-associated serine protease have to be considered too. Cell survival and cell death are two major toxicity endpoints that can be rapidly and effectively measured using in vitro experimental models employing cultured mammalian cells [8–10]. Antibacterial surface modification of biomedical materials has evolved as a potentially effective method of preventing bacterial proliferation and biofilm formation on medical devices [11]. Microbial colonization and biofilm formation on implanted devices represent an important complication in, e.g., orthopedic surgery, dental surgery, or during replacement of skin cover after severe post-traumatic conditions (burns and abrasions), and may result in implant failure. Controlled release of antibacterial agents directly at the implant site may represent an effective approach to treat these chronic complications [9].

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