Recurrence was seen in a 75-year-old male patient with nodular clinical lesion and infiltrative pathology with 20mm diameter at inner canthus. Damage to eyelash was seen in 2 (10%) cases, but other complications such as ectropion, trichiasis, atrophic inhibitor Regorafenib and hypertrophic scar, and damage to eye structure were not seen in any patient (Table 2). 4. Discussion Superpulsed CO2 laser with intraoperative histopathological evaluation is a highly appropriate modality for the treatment of periorbital BCC with high cure rate (95.2%) and low complication rate during

36 months of follow-up period. The aim of periorbital BCC treatment is eradication of the tumor to prevent local recurrence, good aesthetic outcome, and preservation of lid function without any injury to eye structure [9]. The best treatment for BCC is Mohs micrographic surgery, a method of tumor removal with histologic margin control for residual malignant cells, which is superior to other treatments. However, it is expensive and time consuming and requires skilled surgical and pathological team [14–16]; it is also not generally available in most

areas of the world including Iran. Determination of BCC pathologic subtype in order to appropriate treatment is very important [22]. High recurrence rate of BCC in eyelid area must be expected according to histopathological

type [23]. Cystic and nodular histopathologic subtypes of BCC are relatively well defined margin, but morphoeic, micronodular, infiltrative, and basosquamous BCCs have frequently ill-defined margin and are considered as high risk or aggressive histopathologic subtypes [5]. Traditional and new versions of CO2 laser were used for treatment of BCC on the head and neck and other sites of body [17–21, 24–29], but Bandieramonte et al. [17] reported the use of CO2 laser microsurgery in the treatment of 26 superficial BCC tumors combined with intraoperatory histopathological AV-951 examination. They concluded that CO2 laser microsurgery appears to be the most effective treatment method only for primary superficial BCC of the eyelid margins without any complication. Humphreys et al. [26] used pulsed CO2 laser for the treatment of primary superficial BCC and concluded that ultrapulse CO2 laser is the most favorable treatment for superficial BCC. Campolmi et al. [27] treated 140 patients with superficial and nodular BCC by superpulsed CO2 laser. In the end of laser therapy, the bed of the treated site was excised for histopathological examination. This technique, in addition to clinical efficacy for superficial BCC, is associated with minimal thermal damage to the surrounding tissue and permits intraoperative histopathological evaluation.