Although off-line quantitative assessment may provide more objective results, simultaneous interpretation P450 inhibitor in vivo during the acquisition of images is required for timely decision. MPI could not be performed immediately after MCE on all patients

due to a tight schedule of routine SPECT studies. Delays in obtaining MPI possibly underestimated the diagnostic accuracy of MPI. Since low feasibility and availability of MPI may restrict its utility at the emergency department, infrastructure would be needed Inhibitors,research,lifescience,medical to realistically use perfusion imaging in the routine clinical practice. In addition, the gating method was not used for about one-third of patients. Gated MPI allows simultaneous evaluation of perfusion and function, and has been shown to result in improved specificity Inhibitors,research,lifescience,medical by differentiating between defects and attenuation artifacts.21) However, we found that the diagnostic accuracy of MPI with and without gating was similar. Seven (11%) patients with true perfusion defects not associated with regional dysfunction were dichotomized as negative on gated MPI and two (6%) patients with attenuation artifacts were dichotomized as positive on MPI without gating. This study was designed to test the diagnostic efficacy in high-risk chest pain patients and the incidence of ACS was higher than in other studies. The diagnostic accuracy of MCE and MPI may be changed in patients with intermediate or low risk chest pain. We

excluded patients Inhibitors,research,lifescience,medical with previous myocardial infarction Inhibitors,research,lifescience,medical because perfusion imaging is unable to differentiate between ACS and previous myocardial infarction. ACS was defined as the development of AMI or documentation of significant coronary artery stenosis that required urgent revascularization, a definition that has been used as a surrogate for unstable angina.12),13) Although it cannot be clearly defined, we included unstable angina in ACS, considering the prognostic implication of the Inhibitors,research,lifescience,medical early detection of unstable

angina. Finally, the small sample size of this study is also a limitation and further studies with enough power are needed to confirm our results. Compared with routinely used troponin I, ECG criteria and even MPI, MCE is more accurate in diagnosing ACS. Early MCE is proposed to be a useful imaging technique in patients presenting to the emergency department with resting chest pain for whom early and accurate diagnosis remains difficult. Acknowledgements Unoprostone We are indebted to Dr. Sung-Cheol Yoon at Ulsan University’s Department of Biostatistics for helpful review of the statistical analysis in the paper.
A 50-year-old woman admitted for sudden onset facial palsy and dysarthria. Three years ago, she suffered from subacute bacterial endocarditis of the aortic valve with cultured organism of Kingella and 3-month antibiotic treatment (ceftriaxone) had been done successfully. On admission, the patient had a temperature of 36.7℃, a blood pressure of 128/54 mmHg, a pulse of 121/minute and a respiratory rate of 20/minute.