Spectrophotometric method was used for determining the level of malondialdehyde (MDA). Statistical Analysis SPSS software, version 16 was used to test the data. Paired samples t test was used to compare continuous variables within groups. Comparison between different groups was performed through two independent samples t-test. In the absence of normal distribution, comparison between groups was made using non-parametric Wilcoxon on signed ranks and Mann-Whitney tests. P Inhibitors,research,lifescience,medical values <0.05 was considered significant. Results The study was conducted on 34 patients, of which 26 were

females and 8 males. Patients’ characteristics are shown in table 1. The mean age in the placebo and treatment groups were 51.8±10.2 and 55.4±8 respectively. There were no significant differences in BMI and WHR between placebo and treatment groups (table 1). Table1 The

mean anthropometric data in the placebo and treatment groups Table 2 shows changes in biochemical markers after probiotic treatment. The fasting blood sugar did not change significantly after probiotic Inhibitors,research,lifescience,medical treatment (table2). Serum triglyceride concentration was reduced in probiotic treated group but the change was not significant (table2). There were no significant differences Inhibitors,research,lifescience,medical in total serum cholesterol, LDL-C, and HDL-C levels, between probiotic and placebo groups (table2). Fasting plasma insulin level did not change in probiotic group compared to placebo group (table2). Table 2 The mean parameters in placebo and treatment groups Although MDA and IL-6 levels were reduced in treatment group, but the changes were not statistically significant (table 2). There were an increase in CRP levels in treatment group compared to placebo, but the change was not significant (table2). Insulin-sensitivity

Inhibitors,research,lifescience,medical was determined through quantitative insulin sensitivity check index Inhibitors,research,lifescience,medical (QUICKI) and insulin-resistance by HOMA IR, FIRI, Bennett’s Index and Ins/gluc ratio but there were no significant changes in these indices (table 2). Discussion Diabetic complication, such as cardiovascular disease on the one hand and the dramatic growth of diabetic isothipendyl incidence on the other, demands a natural and safe solution to control and delay these complications. A strong association has been found between the level of oxidative stress and risk of cardiovascular disease. Oxidative stress not only causes much pathopysiological complication but is also linked to insulin resistance which in turn causes diminished glucose uptake and disposal in peripheral tissues, and increasing glucose production in the liver. It has also been Imatinib molecular weight reported that postprandial hyperlipidemia and hyperglycemia are associated with increasing LDL-C oxidation and higher risk for cardiovascular disease.4 Studies showed that probiotic containing foods may reduce the concentration of serum lipid and decreases both fasting and postprandial blood sugars in human.