According to available

data many key taxa in the Baltic Sea seem tolerant to the pH changes expected within this century (a reduction in pH between 0.2 and 0.4) with the notable exceptions of developmental stages of mussels and cod (Havenhand, 2012). There is, however, a lack of experimental and observational data on pH dependence for many groups. At present there are also very few experiments that have addressed the effects of changing the seasonal pH cycle and the effect from multiple stressors. It has been shown that reduced pH can negatively impact the tolerance of organisms to other stressors, such as low oxygen and changes in salinity (Ringwood DAPT ic50 and Keppler, http://www.selleckchem.com/products/Everolimus(RAD001).html 2002), both of which may be of concern in the future Baltic Sea. Ocean acidification can also affect the speciation and bioavailability of other compounds in seawater such as e.g. metals (e.g. Millero et al., 2009). If the bioavailable concentration of essential trace metals, usually the free metal ions, increases it can be beneficial for organisms at low concentrations. A mesocosm experiment by Breitbarth et al. (2010) in the Baltic Sea with CO2 enriched waters showed increases in bioavailable iron concentrations; the suggested cause

was changes in organic iron complexation and the oxidation rates of Fe(II). This could potentially lead to an increase in primary production in Fe-limited areas. For the Baltic Sea it might also increase the risk of cyanobacteria blooms as several studies have showed the importance of bioavailable Fe for the development of the cyanobacteria Rebamipide blooms (e.g. Breitbarth et al., 2009 and Kozlowsky-Suzuki et al., 2007). The latter study also pointed out oxygen minimum zones as a possible source of bioavailable iron, which could

increase with increasing eutrophication. The impact of ocean acidification on marine trace metal biogeochemistry is far from being completely understood due to a wide range of complex chemical and biological processes. This is the case also for the impact of heavy metals and other pollutants. Hassellöv et al. (2013) showed that in areas with heavy ship traffic the input of acidifying sulfur and nitrogen oxides (SOx and NOx) could have an impact on surface water chemistry. As SOx and NOx react to form strong acids, the impact is a reduction in AT which will lead to surface waters being more susceptible to ocean acidification. How big this effect is over time and in enclosed basins is something that needs further evaluation. There is still a great uncertainty in the regional climate projections. Further development of the regional climate models, including their geographical resolution (see e.g. Kendon et al.