The results did not cause any change in the treatment modality for the patients involved. The exact BPI-ANCA values in 2010 were compared with the values from 2002 to 2006 for the EIGSS and the non-operated groups of patients (Table 2): in the EIGSS group, the values before and after EIGSS showed a significant reduction in both BPI-ANCA IgG levels (P < 0.001 [CI: 62–379%]) and BPI-ANCA IgA levels (P = 0.01 [CI: 15%–202%]). These reductions were due to decreases found in the subgroups of patients intermittently or chronically colonized in their lungs, as there were no significant differences in the subgroup of non-infected patients (Table 3). No significant changes were seen

within the non-operated control group (P = 0.55

and P = 0.46). Thirteen patients had HKI-272 mw IgA levels above ITF2357 supplier 53 U/l (upper normal limit) before surgery. Eleven patients had IgG levels above 38 U/l (upper normal limit) before surgery. Both groups showed a significant decrease in the values by subgroup analyses (P < 0.05; P < 0.001). The changes of BPI-ANCA antibodies levels in the EIGSS group were compared with those of the non-operated control group. The EIGSS group showed a significant reduction in both IgG BPI-ANCA (P < 0.001 [CI: 51–337%]) and IgA BPI-ANCA values (P = 0.02 [CI: 10–175%]). In the 14 patients who had bilateral sinus samples cultured 6 months postoperatively, 10 patients had negative cultures, two showed bilateral growth of P. aeruginosa, one had bilateral growth of A. xylosoxidans, and 1 had unilateral growth of A. xylosoxidans. Altogether, the 14 patients showed an average decrease in BPI-ANCA IgG of 51 U/l (range from −11 to +311) and an average decrease in BPI-ANCA IgA of 70 U/l (range from −30 to +680); one chronically lung infected patient had a small increase in BPI-ANCA IgG, and one intermittently colonized patient had a small increase in BPI-ANCA IgG and IgA. The levels of BPI-ANCA IgA were measured pre- and postoperatively Aspartate in all 35 LTX CF patients; six patients had negative IgA values pre- and postoperatively, four patients had increased postoperative values (mean increase:

89 U/l), and 25 patients showed decreased postoperative values (mean decrease: 620 U/l). Using a two-sample paired t-test for all 35 patients, the total decrease was found to be highly statistically significant (P < 0.001). The levels of BPI-ANCA IgG were only available pre- and postoperatively in 26 LTX CF patients. Ten patients had negative IgG levels pre- and postoperatively (below 50 U/l), three patients had increased postoperative values (mean: 225 U/l), whereas 13 patients had decreased postoperative values (mean: 713 U/l). Using a two-sample paired t-test for all 26 patients, the total decrease was also found to be statistically significant (P = 0.02). Of the 53 EIGSS patients, precipitating antibodies were available in 47 patients and total anti-Pseudomonas IgG were available in 40 patients.