Despite this, experiments in which all four test strains were included were consistent in the trend to greater A-1210477 adherence among isolates carrying the prophage (Table 2). Figure 2 Comparison of the adherence and invasion of C. jejuni test isolates and XAV 939 controls strains. A. adherence as % of input, B. invasion expressed as the % invaded divided by the total bacteria adherent. Experimental replicates: 81-176, n = 10; 00-2538, n = 9; 00-2544, n = 5; 00-2425, n = 8; 00-2426, n = 6; E. coli Top 10 strain, n = 10 Table 2 Comparison of three separate adherence and invasion experiments Isolate used Repotrectinib clinical trial Input bacteria (cfu/ml) Adherent bacteria (cfu/ml) Adherent bacteria as % of input Invaded bacteria (cfu/ml) Invaded bacteria as % of input % Invaded/adherent (%I/IA) Experiment 1             81-176 (+ve control) (5.2 ± 0.8) × 107 (3.3 ± 1.0) × 106 6.5 (6.3 ± 2.2) × 105 1.22 18.8 00-2544 (+ prophage) (3.7 ± 0.2) × 107 (3.8 ± 1.2) × 105 1.0 (2.7 ± 1.1) × 104

0.07 7.0 00-2538 (+ prophage) (3.7 ± 0.9) × 107 (8.7 ± 0.1) × 105 2.4 (2.0 ± 0.8) × 105 0.54 23.0 00-2425 (+ prophage) (4.1 ± 0.4) × 107 (6.4 ± 0.8) × 105 1.6 (2.0 ± 0.4) × 105 0.48 31.9 00-2426 (− prophage) (4.1 ± 0.1) × 107 (1.2 ± 0.4) × 105 0.3 (1.0 ± 0.7) × 103 0.002 0.8 E. coli Top10 (invasion -ve) (2.2 ± 0.1) × 107 (5.2 ± 1.0) × 105 2.3 (9.5 ± 0.2) × 103 0.042 1.8 Experiment 2

            81-176 (+ve control) (2.1 ± 0.5) × 107 (3.5 ± 1.2) × 105 1.6 (2.2 ± 0.3) × 105 1.04 64.3 00-2544 (+ prophage) (1.8 ± 0.8) × 107 (3.5 ± 2.4) × 105 1.9 (6.5 ± 1.5) × 104 0.33 18.8 00-2538 (+ prophage) (3.4 ± 0) × 107 (3.9 ± 2.3) × 105 1.1 (7.0 ± 0.9) × 104 0.20 17.9 00-2425 (+ prophage) (3.3 ± 0.6) × 107 (5.6 ± 1.5) × 105 1.7 (8.4 ± 3.5) × 104 0.26 15.0 00-2426 (− prophage) (3.4 ± 0.2) × 107 (4.0 ± 2.1) × 104 0.1 (8.7 ± 3.3) × 102 0.003 2.2 E. coli Top10 (invasion -ve) (1.8 ± 0.2) × 107 (1.7 ± 0.9) × 105 tuclazepam 1.0 (9.6 ± 1.6) × 103 0.055 5.7 Experiment 3             81-176 (+ve control) (3.4 ± 0.1) × 107 (1.8 ± 0.3) × 106 5.4 (1.0 ± 0.6) × 105 0.30 5.6 00-2544 (+ prophage) (2.3 ± 0.3) × 107 (3.6 ± 1.3) × 105 1.6 (4.1 ± 2.0) × 104 0.18 11.4 00-2538 (+ prophage) (3.8 ± 0.4) × 107 (6.3 ± 2.8) × 105 1.7 (1.3 ± 0.3) × 105 0.33 20.2 00-2425 (+ prophage) (4.3 ± 1.0) × 107 (1.1 ± 0.2) × 106 2.5 (2.5 ± 1.0) × 105 0.58 22.8 00-2426 (− prophage) (3.8 ± 1.6) × 107 (1.6 ± 0.3) × 105 0.4 (5.5 ± 6.0) × 102 0.001 0.35 E.