11 This study is one of the first estimates provided for CG in th

11 This study is one of the first estimates provided for CG in the general population using clinical interviews. They found a prevalence of 4.8% for complicated grief disorder within the general population. Overall, 1089 participants were found to be currently experiencing grief. Of these, 277 were diagnosed with

CG, which equals a conditional prevalence of 25.4% in the population. Interestingly, while the authors report inflated rates for anxiety and depression in people with CG, comorbidity was not found for the vast majority of participants. As such, CG may be considered to be both a distinct disorder, but also Inhibitors,research,lifescience,medical as sellekchem existing along a continuum, rather than as a clear taxon.27 The highest Inhibitors,research,lifescience,medical prevalence rate was found to be in the 75- to 85-year-old age-group, with a rate of 7%, as compared to 4.8% for older adults overall. In Japan, an epidemiological screening study was recently conducted29 using a five-item scale that evaluated intrusions, avoidance, estrangement from others, trouble accepting the death, and interference of grief in daily life. Participants were 40 to 79 years old; however, the study included only participants who reported bereavement, which may Inhibitors,research,lifescience,medical be a bias because there are people in the general population

who do not report bereavement at all. The authors found what can be considered a conditional probability of 2.4% in that population. Both studies converged, despite methodological differences, on the finding that PGD patients are few in the general population. Furthermore, their number is age-dependent. Indeed, for biological reasons, Inhibitors,research,lifescience,medical older people are more likely to be affected by bereavement involving persons in their social network. Further threads in prolonged grief disorder research Proper research on a (new) psychological disorder must not focus

on diagnostics, assessment, prevention, and treatment alone. While these aspects of research are important, we argue that a core understanding and appreciation of the disorder must also be promoted. Inhibitors,research,lifescience,medical It should be noted that the recent edition of the Handbook of Bereavement: Research and Practice by M. S. Stroebe and colleagues30 provides a comprehensive collection of the major theories and impulses on these aspects. Stroebe and Shut31 proposed a systematic model of grief in general, the dual-process model in concordance with Rubin’s32 earlier two-track model of bereavement. They proposed that a loss-oriented process, Entinostat whereby self-confrontation or avoidance can provide alleviation, allowing an individual to rebuild their life, has to be distinguished from a restoration-oriented process, where the individual may cope with the loss by engaging in new relationships and tasks. According to the model, these two processes represent individual differences in terms of alternatives or individual styles used by different people but may, however, also occur within the same person as an oscillating process.

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