6 +/- 9.5 years) and 43 selleck chemicals llc healthy controls (30.4 +/- 6.7 years). Region of interest analysis was conducted on the images acquired via MRI. Results: Although hippocampal volumes were similar in healthy and patient groups, there was a significant interaction between genotype and diagnosis on hippocampus volumes. Post-hoc ANCOVA showed that hippocampal volumes of S/S homozygous depressed patients were smaller compared to healthy controls in both hemispheres. Conclusion: The 5-HTTLPR polymorphism has an effect on hippocampal volumes of depressed patients, which is apparent only in S/S genotype. It seems that decreased neurogenesis by effects of reduced serotoninergic transmission may be responsible
for smaller hippocampal volumes observed in S/S homozygous depressed patients. Copyright (C) 2010 S. Karger AG, Basel”
“Background. This study examines the relevance of the World Health Organization (WHO) optimal range for body mass index (BMI) of 18.5-25 kg/m(2) to morbidity in older women.
Methods. Data were from 11,553 women who completed five mailed surveys at 3-year intervals between 1996 (age 70-75 years) and 2008 (age 82-87 years). Incidence and prevalence of diabetes mellitus (DM), hypertension, heart disease, and osteoporosis;
hospital admissions; and mortality were assessed. The association between BMI in 1996 and each outcome was examined using logistic regression models with repeated measures and a proportional hazards model for survival.
Results. There were consistent associations between increasing BMI and increasing incidence and prevalence of DM, hypertension, and heart disease SN-38 concentration and between increasing BMI and decreasing risk of osteoporosis. The association with hospital admission was J shaped and lowest for BMI of 22-24 kg/m(2), whereas the association with
mortality was U shaped, being lowest for BMI of 25-27 kg/m(2). These associations were not affected by excluding women with cancer or excluding the first 5 years of follow-up.
Conclusions. These results illustrate the complexity of Mannose-binding protein-associated serine protease determining the optimal BMI range for women who survived to age 70-75 years. Although the WHO recommendation is appropriate for DM, hypertension, heart disease, and hospitalization, a slightly higher BMI range may be optimal for osteoporosis and mortality.”
“Objectives: Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paraventricular nucleus (PVN) of rats with or without immobilization stress. Methods: The rats were subjected to immobilization stress 2 h/day for 3 weeks. The effect of ziprasidone (2.5 mg/kg, 21 days) on CRF mRNA expression was determined using in situ hybridization of tissue sections from the rat hypothalamic PVN. Haloperidol (1.