Suspicion of an aneurysm of the abdominal aorta raised at presentation and a CT-scan was made. No acute pathology was seen except a dilatation of the stomach and small intestine. Laboratory results showed a leucocytes count of 8.4·109/L (normal reference value: 4–10 ·109/L), CRP concentration of 661 mg/L (0.8-2 mg/L), creatinine level of 548 μmol/L (45–100 μmol/L) with a glomerular filtration rate of 9 mL/min/1.73 m2 and a lactate level of 3.9 mmol/L #ATM Kinase Inhibitor ic50 randurls[1|1|,|CHEM1|]# (<1.8 mmol/L).

Additional conventional chest X-rays was also made without pathological findings. Based on the clinical presentation and laboratory results we performed a laparotomy, which showed no abnormalities. He was admitted into the Intensive Care Unit (ICU) for pulmonary and cardiovascular support. During the first five days of admission he Gilteritinib solubility dmso was septic and required cardiovascular and pulmonary support. Continuous Venovenous Hemofiltration (CVVH) for acute kidney failure was started. The first blood cultures showed a staphylococcus aureus. At that time, the patient was treated with Tobramycine and Cefotaxim as prophylaxis for ventilator-associated pneumonia in combination with Orabase protective paste. A Positron Emission Tomography- Computed Tomography scan (PET-CT scan) and several CT-scans were performed, but did not show a focus. After a stay on the ICU of one month with

several complications he stabilized and was discharged. Complications included re-intubation, a central venous line infection with Enterococcus Faecium, an ischemic cerebrovascular accident in the left fronto-occipital region, an ileus and a segmental ischemic colitis with deep ulcers in the transverse colon. The lactate levels and CRP concentrations Calpain decreased to near normal values (Figure 1). Within a few days on the ward he developed a pneumosepsis,

which was treated with Augmentin. When the patient deteriorated he was abstained from further treatment after consultation with patient and family. He deceased within 24 hours. Figure 1 C-reactive protein and lactate concentrations over time of the first case. A C-reactive protein concentrations and B Lactate concentrations. C-reactive protein levels and lactate concentrations decreased to near normal values during the ICU stay. Second case The second patient was a 60 years-old woman. She presented in the ED with acute intense pain in the lower abdomen. One day earlier she started vomiting. Within the last six months she had several attacks of abdominal pain. The medical history included a laparoscopic cholecystectomy. On physical examination she had a tachycardia and was tachypnoeic. The lower abdomen was tender and a mass was palpated. A rectal and vaginal exam showed no abnormalities. Laboratory results demonstrated a leucocytes count of 18.1·109/L, CRP 4 mmol/L and no abnormal kidney or liver function parameters. Arterial gas showed a pH of 7.71 (normal ref.