Plants of the genus Mentha produce a class of natural products known as mono-terpenes (C10), characterized by p-menthone skeleton. Members of this genus are the only sources for the production of one of the most economically important essential oil, menthol, throughout the world [12]. Mentha piperita, commonly called peppermint, is a well-known herbal remedy used for a variety of symptoms and diseases, recognized for its carminative, stimulating, antispasmodic, antiseptic, antibacterial, and antifungal activities

[4, 13, 14]. However, their use for clinical purposes is limited by the high volatility of the major compounds. selleck inhibitor Due to their high biocompatibility [15] and superparamagnetic behavior, magnetite nanoparticles (Fe3O4) have attracted attention to their potential applications especially

in biomedical fields [16, 17], such as magnetic resonance imaging [18–20], hyperthermia [21], biomedical separation and purification [22], bone cancer treatment [21], inhibition of biofilm development [23, 24], stabilization of volatile organic compounds [25], antitumoral treatment without application of any alternating magnetic field [26], drug delivery or targeting [27–33], modular microfluidic system for magnetic-responsive controlled drug release, and cell culture [34].This paper reports a new nano-modified prosthetic device surface with anti-pathogenic CH5183284 concentration properties based on magnetite nanoparticles and M. piperita essential oil. Methods Materials All chemicals were used as received. FeCl3 (99.99%), FeSO4·7H2O (99.00%), NH3(28% NH3 in H2O, selleckchem ≥99.99% trace metal basis), lauric acid (C12) (98.00%), CHCl3 (anhydrous, ≥99%, contains 0.5% to 1.0% ethanol as stabilizer),and CH3OH (anhydrous, 99.8%) were purchased from Sigma-Aldrich. Prosthetic device represented by catheter sections were obtained from ENT (Otolarincology), Department of Coltea Hospital, Bucharest, Romania. crotamiton Fabrication of nano-modified prosthetic device For the fabrication of the nano-modified prosthetic device, we used a recently published

method [35] in order to design a new anti-pathogenic surface coated with nanofluid by combining the unique properties of magnetite nanoparticles to prevent biofilm development and the antimicrobial activity of M. piperita essential oil. M. piperita plant material was purchased from a local supplier and subjected to essential oil extraction. A Neo Clevenger-type apparatus was used to perform microwave-assisted extractions. Chemical composition was settled by GC-MS analysis according to our recently published paper [36]. Magnetite (Fe3O4) is usually prepared by precipitation method [37–39]. The core/shell nanostructure used in this paper was prepared and characterized using a method we previously described [40].