Additionally, the children with autism in our study recruited other brain Dacomitinib mw regions to a greater degree than TD children while viewing faces with averted gaze. At even the highest thresholds explored, significantly increased activity relative to that in the TD group was observed within somatosensory cortex (BA 2). As our paradigm encouraged each group to fixate on the eyes, these fMRI findings of somatosensory cortical

activation in the ASD group are consistent with data from previous fMRI and eye tracking studies suggesting that children with ASD, unless otherwise instructed, may spontaneously use alternative Inhibitors,research,lifescience,medical strategies to process or interpret information in faces (e.g., Klin et al. 2002; Pelphrey et al. 2002; Wang et al. 2004; Dapretto et al. 2006; Wang et al. 2007). Further investigations of the fixation behavior of children with autism while viewing faces not only of varying emotions but also of varying Inhibitors,research,lifescience,medical eye gaze may be fruitful in identifying these

potentially unique strategies. Furthermore, employing eye and emotion-related dynamic facial stimuli rather than stationary faces, as in the present study, may enrich our preliminary understanding Inhibitors,research,lifescience,medical of how dynamic gaze and emotion cues may modulate one another in the brain (Pelphrey et al. 2007). The findings of our Inhibitors,research,lifescience,medical study are also in line with other data reporting decreased frontal brain activity in children with autism to emotional and social cues, suggesting that children who develop autism may have reduced integrity of frontal-posterior brain connections (Just et al. 2004, 2007). Several fMRI Inhibitors,research,lifescience,medical studies in autism have reported reduced left IFG activity in response to social cues, and both functional and structural data have supported a dysregulation model, whereby desynchronized and reduced prefrontal response during social tasks are results of distally reduced, and possibly locally

increased, cortical connectivity (Courchesne et al. 2001; Herbert et al. 2004; Just et al. 2004, 2007). The results of our study are consistent with this theoretical explanation, but cannot directly address TCL it. Our experimental set-up with cross-hair fixation points preceding eye stimuli was designed to prevent gaze aversion or reduced fixation on the eyes in the ASD group, and our eye tracking data showed no group differences in gaze behavior in either gaze direction condition, making it unlikely that gaze aversion could have explained our results. Equivalent activation among ASD and TD children in visual-processing regions including the fusiform gyrus, which is critical for processing faces, further suggests that ASD and TD children spent equal time looking at the faces.