Although there are prom ising developments in interventional cardiology, late rest enosis is still an unsolved problem of interventional procedures. Hemodynamic restenosis occurs after a period of about 12 Weeks in 30 45% of the cases treated with PTCA and 20 30% of the cases with additional coronary stent implantation using bare metal stents. Yumino et al. found a high prevalence Dorsomorphin of OSA in patients with acute coronary syndrome. In these patients OSA appeared to be an independent predictor of clinical Inhibitors,Modulators,Libraries and angiographic Inhibitors,Modulators,Libraries outcomes after percutaneous coronary inter vention. However, there are no data on the course of coronary artery disease after elective PCI in sta ble patients with OSA. We hypothesized, that OSA is asso ciated with higher occurrence of restenosis after percutaneous coronary intervention.

Patients and methods Patients Candidates for participation were consecutive patients undergoing elective coronary angiography and percutane ous coronary intervention and clinical suspected noctur nal breathing disorders. All patients underwent overnight polygraphy between 10. 00 p. m and 6. Inhibitors,Modulators,Libraries 00 a. m. and were classi fied as sleep apneics or controls according to data of the apnea hypopnea index. Oronasal airflow was regis tered using a thermistor, abdominal and thoracic respira tion efforts were measured using impendance plethysmography. Oxygen saturation was meas ured using finger pulse oxymetry. The AHI was calculated as the number of respiratory events per hour after manual scoring. Minimal nocturnal oxygen saturation was defined as the lowest saturation reached during sleep after manual exclusion of clear artefacts.

As adopted in previ ous studies a threshold AHI of 10/h was accepted as a diagnostic indicator for obstructive Inhibitors,Modulators,Libraries sleep apnea syn drome. Cardiovascular risk factors were defined as described in a recent study. The study complied with the declaration of Helsinki. All procedures were carried out as routine procedures, regardless Inhibitors,Modulators,Libraries of the study proto col. All patients gave their informed consent. Treatment of OSA All patients with an AHI 10/h were offered CPAP ther apy. Patients with OSA were divided in two groups based on whether they were treated with CPAP. When CPAP was accepted, titration was performed during a second night in the sleep laboratory using an Auto CPAP device super vised by an experienced doctor.

The P95 read out from the titration device was used to calculate constant CPAP. The treatment group comprised all patients who accepted CPAP therapy, long term compliance was evaluated based on a personnel questionaire. Patients were considered to be selleck chemicals CPAP com pliant if they used CPAP on an average 5 h per night, determined at follow up. CPAP therapy was initiated after the PCI and was performed until the date of the second angiographic study.