At 4 hours (sustained response), only Col/Epi and Col/ADP were assessed.\n\nResults: The DDAVP mean (min-max range, mu g/kg) based on the patient’s weight was 0.15 (0.12-0.18). Laboratory values mean (min-max range in

U/dl) baseline for VWF:RCo, VWF:Ag, and FVIII: C were 28 (20-36), 34 (25-42), and 40 (29-48), respectively. After a subcutaneous administration, the laboratory values mean (min-max range in U/dl(-1)) achieved for 1 hour for VWF: RCo, VWF: Ag, and FVIII: C were 109 (72-144), 132 (88-166), and selleck kinase inhibitor 151 (96-198), respectively.\n\nPFA 100 (R) CT (Col/Epi < 134 seconds and Col/ADP < 110 seconds) returned to normal values at 1 and 4 hours after a subcutaneous administration.\n\nConclusion: Y-27632 mechanism of action Subcutaneous low-dose DDAVP therapy is at least effective as 0.3 mu g/kg intravenous therapy for children with

type 1 VWD. This study shows that a wider use of DDAVP should be promoted, especially in developing countries.”
“To identify weather controls of beech diameter growth and masting in southern Sweden, we analyze records of monthly weather, regional masting record, and tree-ring chronologies from five beech-dominated stands. The results indicate a strong weather control of temporal pattern of masting events in southern Sweden over the second half of the 20th century. Negative summer temperature anomaly 2 years prior to a mast year, coupled with positive temperature anomaly in the year immediately preceding the same mast year, is a characteristic check details weather pattern associated with known mast years. Strong dependence of beech masting behavior on temperature explains the high degree of regional synchronization of masting events. Growth of beech in southern Sweden is strongly and negatively correlated with previous year’s summer temperature and positively – with previous year’s October temperature. The present study does not provide a conclusive answer in identifying a full set of direct and

indirect effects of climatic variables controlling tree-ring growth, since the negative effect of previous year’s summer temperature may be a result of a temperature-controlled increase in the beech nut production in the current year. Consistent and significant negative departures of ring-width index during mast years support the hypothesis about a trade-off between investment of bioassimilates into production of beech nuts and tree-ring growth. Alternative explanation of growth anomalies in mast years, relating such anomaly to a negative impact of previous year’s growing season, was not supported by the data. We found a limited effect of masting on diameter growth in the following years, indicating that decline in the overall wood production, associated with heavy masting, is short term and typically occurs in the year of actual masting. (C) 2010 Elsevier B.V. All rights reserved.