(C) 2011 Elsevier Inc. All rights reserved.”
“The Selisistat research buy purpose of the current study was to examine the role of executive control in fine motor sequencing using a motor-cognitive dual-task paradigm. Younger and older adults performed a sequential tapping task separately and concurrently with a semantic judgment task (Experiment 1) and a mental arithmetic task (Experiment 2). Experiment 1 established that under low cognitive load, older adults were slower and less accurate in sequential tapping than younger adults. Load was manipulated in Experiment 2, and across mental arithmetic difficulty levels, older adults were less accurate in sequential tapping when performing mental arithmetic than younger adults.
At the highest difficulty level, both groups suffered performance costs. In line with gross
motor research, these findings suggest a role for executive functions in fine motor performance in old age.”
“Introduction: Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is selleck compound an important target to enable the understanding of human 5-HT function in vivo. [C-11]CUMI-101, proposed as the first 5-HT1A receptor agonist PET ligand, has been reported to behave as a potent 5-HT1A agonist in a cellular system stably expressing human recombinant 5-HT1A receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue.
Methods: [S-35]-GTP gamma S binding studies were used to determine receptor function in HEK (human embryonic kidney) 293 cells transfected with human recombinant 5-HT1A receptors and in rat cortex and rat hippocampal tissue, following administration of CUMI-101 and standard 5-HT1A antagonists see more (5-HT, 5-CT and 8-OH-DPAT).
Results: CUMI-101 behaved as an agonist at human recombinant 5-HT1A receptors (pEC(50) 9.2). However, CUMI-101 did not show agonist activity in either
rat cortex or hippocampus at concentrations up to 10 mu M. In these tissues, CUMI-behaved as an antagonist with pK(B)s of 9.2 and 9.3, respectively.
Conclusions: Our studies demonstrate that as opposed to its behavior in human recombinant system, in rat brain tissue CUMI-101 behaves as a potent 5-HT1A receptor antagonist. (C) 2011 Elsevier Inc. All rights reserved.”
“Previous research revealed age differences in following the gaze of others. To date, however, investigations have concentrated on only young faces as target stimuli. The present study explored whether varying the age of target stimuli moderated gaze following in younger and older adults. Overall, older participants showed less evidence of gaze following, but this was qualified by the age of the face viewed. Younger participants showed an own-age bias, following the gaze cues of stimuli depicting those in their own age range to a greater extent than stimuli depicting older adults. However, a similar own-age effect was not found for older participants.