Demographic data including cardiovascular risk factors, body mass index (BMI), and history of CAD were recorded. In all, 182 patients with a mean age of 62.1 years (±10.7 years) were studied. Indications for angiography were suspected angina. By WHO criteria an abnormal two-hour glucose was present in 49% of individuals, with 10.4% of these patients having overt DM. An abnormal two-hour glucose was seen in 63.2% of patients with significant CAD compared with 40.3% with normal or insignificant disease (p=0.004); 48.9% of patients with IGT or DM had normal fasting plasma glucose (FPG). In

78% of patients, BMI was over 25kg/m2. In this high risk population with multiple risk factors for CAD, previously undetected IGT and overt DM are very common. Almost two-thirds of patients with significant CAD had abnormal glucose regulation. The use of an FPG test alone Tanespimycin solubility dmso may miss a significant number of patients with unrecognised glucose intolerance. Copyright © 2011 John Wiley & Sons.

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“There is increasing interest in the use of oral hypoglycemic agents in pregnancy. Glyburide (glibenclamide) and metformin Selleckchem ZD1839 are unlikely to be teratogenic. Studies show that metformin crosses the placenta, whereas glyburide does not. Metformin improves ovulation rates in women with polycystic ovary syndrome and preliminary data suggest that it may decrease spontaneous abortions and gestational diabetes (GDM) in these women when used in pregnancy. Glyburide and metformin have shown equivalent glycemic control and neonatal outcomes in randomized controlled trials when compared with insulin, in women with GDM. However, questions remain regarding their use. Traditionally, pregnant women with Type 2 diabetes or GDM have

been managed with insulin but this practice may change in the light of recent trial data. There are few data on the use of PPAR-gamma agonists in pregnancy. Tolerability is likely to be an issue with the use of alpha glucosidase inhibitors. Glyburide, glipizide and metformin appear compatible with breastfeeding, but are still not universally recommended. “
“The aim of this paper is to describe the long-term effect of U-500 insulin use on biomedical outcomes in a cohort of patients with diabetes mellitus. We carried out a case record review of 81 patients Thalidomide from a multicultural population who had received U-500 insulin. We recorded data before the introduction of U-500 and at data collection (February 2007) including: demographic information, weight, insulin dose, HbA1c, lipid profile and blood pressure. The results showed that the mean duration of treatment was 30±22.6 months (range 1–98). The median insulin dose was 292 vs 320 units/day (range 122–600 vs 120–760 units/day). Mean HbA1c at baseline improved from 10.0±1.8% to 8.7±2.0% (p<0.0001). Patients using U-500 insulin for a longer period (>36 months) showed a greater reduction in HbA1c (1.8±1.5% vs 0.99±1.8%, p<0.05). An improvement in HbA1c was seen in all ethnic groups.