However it was not fully investigated that how reserve capacity of single kidney for healthy kidney donor changes after unilateral nephrectomy. The aim of this study was to assess the change of remaining single kidney function after kidney donation and evaluate predictive pre-donation factor for reserved single
kidney capacity in donors. Methods: Total 74 kidney donors who underwent 99mTc-DTPA Scintillation-Camera renography before and after kidney donation were included in this study. The renography measured singl-kidney glomerular filtration rate (sk-GFR) of both kidney before donation and post-donation GFR of remaining kidney during 12 months in donor. We investigated the factors that are associated with reserved capacity of remaining single kidney after donation, such as age, BMI, BSA, serum creatinine for Cock-Croft Gault’s fomula and MDRD GFR, 24 hr urine collection for creatinine clearance selleck kinase inhibitor and kidney volume measured by abdomen CT. Results: After uninephrectomy the mean of serum creatinine increased significantly
(P = 0.000, CH5424802 cell line from 0.77 to 1.07 mg/dL) and the mean measured GFR by the renography declined (P = 0.000, from 112.9 to 74.9 ml/min/1.73 m2). Nevertheless the mean of serum creatinine and mGFR was stabilized during 12 months follow-up period (mGFR at Post-donation, P = 0.165 [6 month 74.9 ± 18.2 vs 12 month 81.4 ± 14.8 ml/min/1.73 m2]). The sk-GFR of remaining kidney significantly increased by 33.6% after uninephrectomy (sk-GFR, P < 0.01 [Pre-nephrectomy 57.9 vs Post-nephrectomy 77.5 ml/min/1.73 m2]). By univariate linear regression BMI, total mGFR, sk-GFR of remaining kidney and total kidney volume at pre-donation was included as independent predictors of change of sk-GFR. Among these, BMI (P = 0.013) and sk-GFR of remaining kidney at pre-donation (P = 0.019) was statistically related to reserved single kidney capacity in multivariate regression analysis. Conclusion: After kidney donation, reserved single kidney capacity showed PtdIns(3,4)P2 significant increase due to adaptive hyperfiltration, especially more compensatory
response in donor with lower BMI and sk-GFR of remaining kidney at pre-donation. TSUCHIMOTO AKIHIRO1, NAKANO TOSHIAKI1, MASUTANI KOSUKE1, MATSUKUMA YUTA1, KITADA HIDEHISA2, NOGUCHI HIDEKO1, TSURUYA KAZUHIKO3, TANAKA MASAO2, KITAZONO TAKANARI1 1Departments of Medicine and Clinical Science, Graduated School of Medical Sciences, Kyushu University; 2Departments of Surgery and Oncology, Graduated School of Medical Sciences, Kyushu University; 3Departments of Integrated Therapy for Chronic Kidney Disease, Graduated School of Medical Sciences, Kyushu University Introduction: Lymphangiogenesis is often observed in both diseased native kidney and kidney allograft, and correlates with interstitial inflammation. However, there is little information about the clinical significance of lymphatic vessels in kidney allograft.