In foods, Maillard reaction is actually a series of subsequent and parallel reactions that can occur simultaneously, influenced by each other as well as by the medium composition
[3]. Hodges proposed that they occur in three different stages, and each one would be characterized by the generation of certain products (markers) that would, then, indicate the severity of the heat treatment as well as the LDK378 loss of nutritional value, due to the blockage of the essential amino acid lysine. Actually the decrease in the protein biological value and the decrease in bioavailability of essential aminoacids (mainly lysine), due to heating or storage, were among the main drivers for the advances about Maillard reaction and products in foods. A few years after Hodge’s publication, in 1955, the discovery of the glycated form of hemoglobin, by Kunkel and Wallenius [4] and, later, in 1968, Rahbar [5] findings that HbA1c (an hemoglobin in which the N-terminal valine of the β chain of HbA is glycated) was elevated in the red blood cells from diabetic patients, confirmed Maillard’s prediction that this reaction happens in vivo and could be implicated in pathological conditions. Advances in this field were accelerated from the earlier 1980s, after Monnier’s
group pioneer work about glycation in lens proteins, proving that cross-linking of long life-span proteins resulted in pathological consequences, which was further observed in other tissues as vascular vessels and collagen [6]. In the sequence, other pioneer works linked glycation Lapatinib cell line to oxidation of macromolecules and the pathological conditions and aging. Several good reviews are now available [1], [7], [8], [9••], [10•], [11], [12], [13] and [14]. The non-enzymatic browning reaction in the human body is referred as glycation, and the products generated are known as Advanced Glycation Endproducts (AGEs). There seems to be a consensus
among several researchers, that Maillard reaction (MR) and Maillard reaction products (MRP) are to be used to describe the non-enzymatic browning reaction in foods (or model systems) while glycation and AGEs are the terms to be used when referring to the reaction occurring within the living organism. Some confusion Galeterone is, yet, found on the use of this terminology since recent published papers use MR and glycation and AGEs and MRP indistinctively as synonyms. The pathways of the in vivo and in vitro reaction have been extensively reported [10•], [13], [15••] and [16] and will not be described in this paper. Irreversible modifications of protein structure, functionality and turnover are due to the cross-linking reaction and AGEs generation. These modifications, in turn, enhance the pathophysiological processes associated with diabetes and kidney diseases, as well as the development of atherosclerosis and neurodegenerative diseases.