Injuries, whether unintentional or intentional, may have devastating effects on the lives of individuals and poses a great burden on public-health budgets [2]. This burden may even increase in the future, since the World Health Organization

(WHO) projected a 28% increase in global deaths due to injury between 2004 and 2030 [1]. Specialized trauma centers all over the world provide initial trauma care and diagnostic Inhibitors,research,lifescience,medical work-up of trauma patients. This work-up is standardized and frequently based on the Advanced Trauma Life Support (ATLS®) guidelines which include a fast and priority-based physical examination as well as screening radiographs supplemented Inhibitors,research,lifescience,medical with selective Computed Tomography (CT) [3]. ATLS guidelines advise to routinely perform Fostamatinib order X-rays of thorax and pelvis and Focused Assessment with Sonography for Tauma

(FAST) in trauma patients. X-rays of the spine and extremities are performed based on clinical suspicion during the secondary survey. Whether or not to perform CT scanning following conventional imaging is defined less clearly in the ATLS guidelines and depends upon national guidelines and local protocols. In recent years CT has become faster, more detailed and more available in the acute trauma care setting. CT Inhibitors,research,lifescience,medical shows high accuracy for a wide range of injuries [4-7] which is reflected by a low missed diagnosis rate [5,8-10]. Hence, the conventional radiological work-up according to the ATLS may not be the optimal choice of primary diagnostics anymore. Furthermore, severely injured patients frequently require secondary CT scanning of many parts of the body after conventional Inhibitors,research,lifescience,medical imaging. Modern multi-detector CT scanners (MDCT) can perform imaging of the head, cervical spine, chest, abdomen Inhibitors,research,lifescience,medical and pelvis in a single examination (total-body CT scanning). The past few years this total-body imaging concept gained popularity as a possible alternative to the conventional imaging strategy. With the use of immediate total-body CT scanning in trauma patients, rapid and detailed information of organ Histone demethylase and

tissue injury becomes available and a well-founded plan for further therapy can be made. In the past, CT scanners were located in the radiology department, frequently even on another floor than the emergency department (ED) where the trauma patient is admitted. The past assumption that total-body CT scanning in severely injured trauma patients is too time consuming may no longer be held, since an increasing number of trauma centers have a CT scanner available at the ED or even in the trauma room itself [11,12]. Several studies evaluated time intervals associated with total-body CT usage in severely injured patients [4,5,8,13-18]. Time intervals focused on are scanning time, time to all diagnosis known and time in the ED.