Nondrug therapy Other successful techniques

that have been shown to improve patient, adherence to medication include the use of cognitive behavioral therapy and the participation in other concurrent nondrug therapy,10 particularly when care is closely coordinated between the clinician prescribing medication and the clinician providing psychotherapy when these roles are separate. In another area of medical treatment, Safren et al59,60 have Inhibitors,research,lifescience,medical shown that in HIV-positive patients, an intervention called Life-Steps, which is a single-session intervention utilizing cognitivebehavioral, motivational interviewing, and problem-solving techniques, improves adherence to HIV antiretroviral therapy. Further study should be directed at specific psychotherapeutic interventions similar to these that support treatment adherence in the pharmacotherapy of depression. Conclusion Antidepressant side effects are a common clinical Inhibitors,research,lifescience,medical challenge, often

jeopardizing treatment adherence and quality of life. Physicians may underestimate the prevalence of side effects and may be reticent to address them proactively out of a Inhibitors,research,lifescience,medical mistaken concern that their impact will be magnified. The successful management of side effects begins with adequate communication and patient education prior to and throughout treatment with antidepressants. In addition, it involves thoughtful differentiation of treatment-emergent side effects from residual depressive symptoms, relapse and recurrence, discontinuation related adverse events, and intercurrent Inhibitors,research,lifescience,medical general medical problems. .Finally, optimal management of side effects involves drawing upon a full array of strategies including dose reduction, changes in the timing of doses or the drug preparation, behavioral strategies, pharmacological antidotes, and willingness to consider switching to other agents. Sound and resourceful management of side effects is an important component in achieving depressive remission and enhancing patient safety and quality of life. Contributor Information Karen Kelly, Department of Family Medicine, Inhibitors,research,lifescience,medical Boston University, Boston, Massachusetts, USA; Depression

Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, 3-mercaptopyruvate sulfurtransferase USA. Michael Posternak, VRT752271 cell line Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. E. Alpert Jonathan, Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Major Depressive Disorder (MDD) is a prevalent illness that is frequently associated with significant disability, morbidity, and mortality. Results from the 2003 National Comorbidity Replication study found that the lifetime prevalence of MDD among American adults is 16.2%, ranking it among the most common and costly medical illnesses.