Of the 86 newborns, 26 were regarded as hypoxic. Activin A concentrations
were measured by means of specific two-site enzyme immunoassays. Activin A concentrations were correlated with newborns’ gender, week gestation, mode of delivery and blood gas measurements. Results: Activin A levels were significantly higher in hypoxic than nonhypoxic newborns (medians, minimum and maximum values: 1.516; 0.149-1.974 versus 0.368; 0.054-1.041 ng/mL, p = 0.0452). Activin A concentration was significantly higher in male newborns (p = 0.0074). Activin A levels were lower in term than preterm babies but Selleck SNX-5422 the differences were not statistically significant (p = 0.2368 in hypoxic, p = 0.2487 nonhypoxic). Mode of delivery did not influence on activin A concentration (p = 0.8293 hypoxic, p = 0.9458 nonhypoxic). The differences of occurrence of intraventricular hemorrhage (IVH) 4EGI-1 clinical trial in both group was not statistically significant (p = 0.61). Conclusions: Umbilical artery activin A combined with other markers of hypoxia could be a useful marker of perinatal hypoxia. Concentration of
activin A is significantly higher in male newborns. The mode and time of delivery have no influence on activin A concentration.”
“Ritodrine hydrochloride ((R,S)-4-hydroxy-alpha-[1-[2-((4-hydroxyphenyl)ethyl]amino)ethyl]benzenemethanol, CAS 26652-09-5) is a direct-acting sympathomimetic agent with a predominant beta-adrenergic activity and a selective action on beta(2)-receptors. A clinical trial was carried out to investigate the pharmacokinetics, pharmacodynamics and safety of ritodrine hydrochloride administered at the doses of 10, 20 and 30 mg p. o. and 10 mg by I. m. route. A four-way randomised crossover design was adopted on 12 healthy female volunteers with a wash-out of at least 14 days. Concentrations of ritodrine and of the pool of ritodrine in plasma and concentrations of Compound Library cell line the pool of ritodrine in urine of volunteers were bioassayed with tandem mass spectrometry. The following pharmacoldnetic parameters were calculated, using the non-compartmental model: C(max), AUC(0-t),
AUC(0-INF), t(1/2), V(d)/f, and Aet after each administration. The distribution volume of ritodrine proved to be about 3 times higher than that of the pool of ritodrine after i.m. injection, confirming the good permeability of ritodrine that massively enters tissue compartments. Statistical analyses of pharmacokinetic parameters ascertained that the p. o. absorption of ritodrine hydrochloride was linearly related with the doses administered in the 10-30 mg range. The pharmacodynamic parameters evaluated complied with the mechanism of action of this drug.”
“Background: Nuclear factor kappa B (NF-kappa B) is considered an important mediator of inflamation, but is also important for developing organs and is constitutive active in neurons in the newborn brain.