Patients presenting with occult OGIB used antithrombotics significantly more often than the ones with visible OGIB (p = 0,049). We found no significant correlation between antithrombotics and P1 or P2 lesion findings in CE. However, when a sub-analysis was performed, there was a significant correlation between anticoagulant drugs and a higher incidence for P1-P2 lesions in the small bowel (p = 0,045). Conclusion: Antithrombotic drugs, whose usage was very frequent JNK inhibitor in vitro in patients presenting with OGIB, were significantly associated with an occult bleeding presentation.Both uncertain bleeding potential (P1)

and high bleeding potential (P2) small bowel lesions were more frequently found in the capsule enteroscopy when the patient was on anticoagulant drugs. Key Word(s): 1. Capsule enteroscopy; 2. OGIB; 3. Antiplatelet; 4. Anticoagulant; Presenting Author: LIANYING YU Additional Authors: QIYI WANG, WEIHONG SHA Corresponding Author: QIYI WANG Affiliations:

guangdong general hospital Objective: The aim of this study was evaluate the mechanisms and preventive effect of different kinds of propton pump inhibitor (PPI) on dual anti-platelet drugs induced gastrointestinal injury. Methods: Seventy male Sprague-Dawley HCS assay (SD) rats were divided into seven groups. Each group contained 10 rats. The rats in blank group received saline for 10ds. Dual anti-platelet therapy including aspirin (Asp) 100 mg/kg/d and clopidogrel (Clo) 75 mg/kg/d for 10ds were given to the rats as control group. Based on the dual anti-platelet therapy, the one in omeprazole (Ome), lansoprazole(Lan), esomeprazole (Eso), pantoprazole (Pan) and rabeprazole (Rab) groups were given Ome 20 mg /kg/d, Lan 20 mg/kg/d, Eso 20 mg/kg/d, Pan 40 mg/kg/d,

Rab 20 mg/kg/d for 10ds, respectively. After 10ds continuous medication, the Lesion index (LI), pathological 上海皓元 index (PI), ICAM-1, microvessel density (MVD) and PGE2 in gastric mucosal were estimated to evaluate the gastric mucosal injury. Results: Compared with control group, the LI and PI in all PPIs groups were decreased significantly, all p < 0.05. The ICAM-1 expressions in all PPI groups were significantly weaker than that in control group, all p < 0.05. The MVD in all PPIs groups were significantly lower than that in control group, all p < 0.05. But there was no difference among different PPIs groups for the above parameters. The PGE2 in gastric mucosa in control and all PPI groups decreased significantly as compared with blank group, all p < 0.05, but no difference was found among the control and all PPIs groups. Conclusion: PPIs can prevent dual anti-platelet drugs induced gastrointestinal injury. The prevention mainly relates to the increasing of intragastric pH but not relates to the improving of MVD and PGE2. Key Word(s): 1. PPIs; 2. clopidogrel; 3. gastric lesion; 4.