Regional anesthesia and analgesia A meta-analysis involving 141 randomized controlled trials reported that patients receiving RG7422 datasheet regional anesthesia (either spinal or epidural anesthesia) had lower rates of pneumonia and respiratory failure as compared with those under general anesthesia [87]. However, another systematic review involving 15 randomized trials of 2,162 patients focusing on hip fracture surgery found that the postoperative pneumonia rates were almost the same (5.1% in regional vs 5.5% in general anesthesia) [88]. Postoperative epidural analgesia is associated with the lowest

rate of PPCs compared with other forms of analgesia among patients after major abdominal surgery [21]. However, to date, there seems to have been no study investigating the difference in PPCs among those patients undergoing

hip fracture surgery. Further investigations are needed to demonstrate the beneficial effects of regional anesthetics and analgesics on PPCs among patients selleck products receiving hip fracture surgery. It is conceivable that spinal/epidural hematoma may occur in anticoagulated patients who are receiving regional anesthesia or analgesia. However, a recent study found that well-controlled anticoagulation was not associated with an increased risk of postoperative spinal/epidural hematoma [89]. Conclusion Hip fracture is a common cause of morbidity and mortality among the elderly. PPCs play an important role in altering the risk for patients undergoing Arachidonate 15-lipoxygenase hip fracture surgery. Physicians should perform preoperative pulmonary assessment, taking into account the patient-related risk factors such as advanced age, poor general health

status, current infections, underlying cardiopulmonary diseases, hypoalbuminemia, and impaired renal function. At the same time, efforts should be made to optimize the patient’s medical conditions prior to surgery, and preoperative interventions such as lung expansion techniques and thromboprophylaxis should be employed in order to minimize the pulmonary risk. Conflicts of interest None. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References 1. Dharmarajan TS, Banik P (2006) Hip fracture. Risk factors, preoperative assessment, and postoperative management. Postgrad Med 119:31–38CrossRefPubMed 2. Cooper C, Campion G, Melton LJ (1992) Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2:285–289CrossRefPubMed 3. Raaymakers EL (2006) Fractures of the femoral neck: a review and personal statement. Acta Chir Orthop Traumatol Cech 73:45–59PubMed 4.