The aim of this study is to determine
the sensitivity,specificity,positive and negative predictive values and diagnostic accuracy of this office based rapid screening kit.Colonoscopy to date is the Gold Standard for screening of CRC. Methods: stools were collected from patients and controls only after at least 1 week from colonoscopy.The stool has to be formed again by a natural bowel movement and no inflammation/injury has occurred due to endoscopic procedure.The test was done according to manufacturer’s instructions. Results: Preliminary result of this on-going study on 76 patients with CRC and 107 controls is as shown in the table. Sensitivity = 69/76, 90.70%(95% CI 82.19–95.47) Specificity = 104/107, 97.2% (95% CI 92.08–99.04) Positive predictive value
: 69/72, 96.7% (95% CI 88.45–98.57) Negative predictive value : 104/111,94.5% (95% CI87.55–96.91) Diagnostic Accuracy = 94.1% (95% Selleck MAPK Inhibitor Library CI 90.23–97.01). Conclusion: The M2PK screening tool is a highly sensitive and specific test for screening of CRC. Key Word(s): 1. M2PK; 2. Colorectal carcinoma; 3. Screening; Colonoscopy results M2-PK test CRC No-CRC positive 69 3 negative 7 104 Presenting Author: YOOJIN LEE Additional Authors: EUN SOO KIM, KYUNG SIK PARK, KWANG BUM CHO, SEONG WOO JEON, MIN KYU JUNG, SUNG KOOK KIM, JOONG GOO KWON, JIN TAE JUNG, EUN YOUNG KIM, BYUNG IK JANG, KYEONG OK KIM, CHANG HUN YANG, WAN JUNG KIM, HYUNG JIN KIM, HYANG EUN SEO, JAE HYEOK CHOI, EUN SUNG CHOI Corresponding Author: EUN SOO KIM Affiliations: Gastroenterology; Department of internal medicine; Department of Internal Medicine Objective: The risk of cancer varies with the subtype of MK-2206 in vitro the colorectal laterally spreading tumors (LST).However, there are
variable visual interpretations GPX6 among endoscopists.The aim of this study was to evaluate interobserver agreement and accuracy for endoscopic classification of LST subtypes among experts and trainees. Methods: Forty LST images were collected and independently reviewed by 14 gastroenterology experts and 10 trainees. All investigators recorded their findings asone of the four categories(homogeneous, nodular mixed, flat elevated, and pseudodepressed). Agreement was expressed by a kappa estimate (k). The accuracy was assessed by agreement with gold standard which was based on the gross morphology of resected specimen. Results: 41 (45.1%)out ofthe possible 91 pairwise kestimates among experts weregreater than 0.75,indicatingexcellent agreement whileonly 2 (4.44%) out of the 45 pairwise k estimates among trainees weregreater than 0.75. The mean kappa value was 0.73 (range 0.54–0.86) for experts and 0.56 (range 0.36–0.83) for trainees.The agreementfor individual LST subtype in trainee group were significantly lower than thoseinthe expert group, except LST subtype of flat elevatedwhich showed similar agreement between two groups (0.96 vs. 0.94).Also, the overall accuracy of LST was higher in experts (k = 0.811) than in trainees (k = 0.