The aim of this study was to evaluate the short-term efficacy and duration of response to combined medical and surgical therapy. Methods: This was a retrospective review of CD patients with complex perianal fistula treated with

infliximab and (or) immunomodulator after primary seton drainage between September 2012 and April 2013. Complex perianal fistula was identified by examination under anaesthetic (EUA) and pelvic MRI. Results: Fourteen CD patients with complex perianal fistula (9 male; and median age 24 years) received seton drainage and two of them received additional surgery of enterostomy. Infliximab (IFX) and (or) azathioprine (AZA) was started 7 to 34 days (median 15 days) later after drainage. Nine of 14 patients (64%) had Saracatinib a complete response (median follow-up 23 weeks, range 13–30 weeks). One patient (7%) had a partial response (follow-up 6 weeks), defined by decreased drainage but not removed seton. Four patients (29%) had no response because of relapsed (median 20 weeks, range 8–31 weeks), but one had a complete

(follow-up 14 weeks) and three had a partial response (median 22 Nutlin-3a chemical structure weeks, range 8–31 weeks) to retreatment (received seton drainage again). Among the 9 patients with complete response, two received AZA, five received IFX and two received IFX+AZA initially. But 3 of these changed the initial therapy protocol, including 2 were added AZA to initial IFX therapy and 1 stopped IFX+AZA treatment for acute appendicitis. Both of the 2 patients with enterostomy had a complete response. Conclusion: Surgery-based combined therapy is effective for complex perianal fistula in CD patients. IFX with or without AZA may help over two thirds of patients to get complete remission. Short tern relapse could be effectively dealt with repeat seton drainage. Whether IFX+AZA is better than mono therapy need further investigation. Key Word(s): 1. perianal fistula; 2. Crohn’s disease; 3. therapy; Presenting Author: CHENG CHENG JI Additional Authors: medchemexpress XIANG GAO, MIN ZHI, MIN ZHANG, JIAN TANG, HUANG WEI CHEN, PIN JIN HU Corresponding Author:

XIANG GAO Affiliations: The sixth affiliated hospital of Sun Yat-sen University Objective: Anemia is a common complication of patients with Crohn’s disease (CD). The aim of this study is to estimate the characteristics of anemia in CD. Methods: We performed an observational, descriptive, retrospective study in patients with CD followed-up between 2011 and 2013 in outpatient clinc in the Sixth Affiliated Hospital of Sun Yat-sen University. The study group with proved CD underwent the analysis according to age, signs, clinical course and activity of the disease. Complications, treatment option and/or surgery were recorded. The routine blood test (RBC, Hb, PLT, MBC, MCH, MCHC), erythrocyte sedimentation rate (ESR), high sensitive C-reactive protein (hs-CRP) were tested for each patient at first visit and subsequent visits at 3 month, 6 month, 9 month and 12 month.