The Caucasian group were less likely to be enrolled in an active HCC surveillance program than the sub-Saharan African or SEA groups (17% vs 32% vs 58%; p = 0.05). However there was no difference in the number of patients in the three groups that underwent potentially curative therapy which was defined as liver transplantation, liver resection or radiofrequency ablation (sub-Saharan Africans 32% vs SEAs 42% vs Caucasians 18%; p = 0.07). Overall there was no difference in survival between the three groups (p = 0.38). Conclusion: This small study shows that sub-Saharan Africans present with HCC at a younger age which supports previously published data. In addition
EX 527 datasheet Caucasians are significantly less
likely to be in an active HCC surveillance program. This finding may be related to current guidelines for HCC surveillance which differ between ethnic groups, recommending screening Caucasians who are cirrhotic, while introducing screening in SEA and sub-Saharan African patients based on viral hepatitis status and age in addition to disease stage. M OOI, B SHADBOLT, GC FARRELL, NC TEOH The Canberra Pexidartinib cell line Hospital, ACT, Australia Background: Acute variceal bleeding due to underlying cirrhosis is associated with significant morbidity and mortality. While there are no reliable methods for Uroporphyrinogen III synthase predicting the development of oesophageal varices, AASLD guidelines recommend that all newly diagnosed cirrhotics, should
undergo endoscopic variceal screening (G. Garcia-Tsao et al; Hepatology; 46; (3), 2007 :922–938). Aim: To determine the proportion of patients with cirrhosis submitted to oesophageal variceal surveillance and banding ligation (EVL) according to clinical guidelines. Methods: We performed a retrospective analysis of a prospectively-entered database which includes patients with chronic liver disease who underwent variceal surveillance between January 2009 and December 2012 at The Canberra Hospital (TCH), and the data were compared to all patients diagnosed with chronic liver disease at the same institution over the same period. We also retrospectively reviewed all patients who presented to the Emergency Department at TCH with confirmed variceal bleeding. The main outcome measure was mortality. In the cohort of patients that presented with variceal bleeding, we determined whether they had previously identified liver disease, endoscopic variceal surveillance, and respective surveillance intervals. Results: 336 of a total of 1399 patients with chronic liver disease underwent variceal surveillance over the 4-year study period. Amongst the 336 patients identified, 6 had Child-Pugh (CP) A, and the majority CP-B (n = 232) or CP-C (n = 98) cirrhosis.