The Person-centred Climate Questionnaire-Patient version was completed

by 145 mentally lucid residents in 17 Norwegian long-term care facilities. Reliability was assessed by Cronbach’s alpha and item-total correlations. Test-retest reliability was assessed by paired samples 3-deazaneplanocin A inhibitor t-test and Spearman’s correlation. To explore differences based on facility and resident characteristics, independent-samples t-test and one-way ANOVA were used. Results. The content validity index for scales was satisfactory. The Person-centred Climate Questionnaire-Patient version was internally consistent and had satisfactory test-retest reliability. The climate was experienced as highly person-centred. No significant differences were found, except that residents in larger facilities experienced the climate as more person-centred in relation to everyday activities (subscale 2) than residents in smaller facilities. Conclusion. The Norwegian version of the Person-centred Climate Questionnaire-Patient version can be regarded as reliable in a long-term care facility context. Perceived degree of person-centredness was not associated with facility or resident characteristics, such as the number of

residents, having a sensory garden or knowing that one has a primary caregiver. Relevance to clinical practice. A person-centred climate can be attained in different kinds of long-term care facilities.”
“Studies of renal cell carcinoma (RCC) have led to the development of new molecular-targeted drugs but its oncogenic origins find more remain poorly understood. Here, we report the identification and critical roles in renal carcinogenesis for DDX31, a novel nucleolar protein upregulated in the vast majority of human RCC. Immunohistochemical overexpression of DDX31 was an independent prognostic factor for patients with RCC. RNA interference (RNAi)-mediated attenuation of DDX31 in RCC cells significantly

suppressed outgrowth, whereas ectopic DDX31 overexpression in human 293 kidney cells drove their proliferation. Endogenous DDX31 interacted and colocalized with nucleophosmin (NPM1) in the nucleoli of RCC cells, and attenuation of DDX31 or NPM1 expression decreased pre-ribosomal RNA biogenesis. Notably, in DDX31-attenuated cells, NPM1 was translocated from nucleoli to the nucleoplasm or cytoplasm where it bound to HDM2. As a result, HDM2 binding PFTα mw to p53 was reduced, causing p53 stablization with concomitant G1 phase cell-cycle arrest and apoptosis. Taken together, our findings define a mechanism through which control of the DDX31-NPM1 complex is likely to play critical roles in renal carcinogenesis. Cancer Res; 72(22); 5867-77. (C) 2012 AACR.”
“The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species. (C) 2012 Elsevier Ltd. All rights reserved.