The present data provide valuable information in order to clarify the relevance of kinin Osimertinib chemical structure receptors in regulating vascular physiology and may point to new approaches regarding its correlation with endothelial dysfunction, oxidative stress and NO availability. Supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP 2007/59039-2, 2008/06676-8), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). “
“The importance of physical exercise for the control

of hypertension is well documented and is the subject of guidelines from the American College of Sports Medicine [32]. A reduction in blood pressure buy ATM Kinase Inhibitor in spontaneously hypertensive rats (SHR) has been found after chronic physical training by swimming [25] and [40] or running [19], [45] and [46]. The mechanisms involved in the reduction of blood pressure (BP) could be dependent on the type of exercise training.

There is evidence that the acute and chronic hemodynamic responses to swimming are different from the responses to running [1], [9] and [43]. Studies have shown that water immersion causes an immediate translocation of blood from the dependent limbs and an increase in the intrathoracic blood volume that augments the cardiac output via increased end-diastolic and stroke volume due to the effect of increased cardiac muscle length on the contractile force of the cardiac

muscle. The stretching of the atrium also results in a compensatory ANP secretion [30]. Thus, the reduction of blood pressure that is induced by exercise training could be involved in different neural or hormonal adaptations. Atrial natriuretic peptide (ANP) is a hormone that promotes acute vasodilatation, natriuresis and diuresis next with a consequent reduction in blood pressure [34]. Normotensive rats that received a prolonged infusion of ANP, resulting in increased plasma levels of this hormone, showed sustained hypotension [14]. Additionally, ANP knockout mice or natriuretic peptide receptor A (NPR-A) knockout mice have increased peripheral vascular resistance, hypertension and ventricular hypertrophy [22] and [28]. Moreover, elevated levels of ANP in hypertensive individuals could partially compensate for the high levels of vasoconstrictor hormones originating primarily from the renin–angiotensin–aldosterone system [41]. It is known that under physiological conditions, the primary stimulus for the secretion of ANP is the distension of the atrial chamber [7]. Among the factors that stimulate ANP secretion are increased concentrations of endothelin and vasopressin, tilting of the head downward [34] and immersion in water [26] and [39]. It has been shown that training by swimming increased the expression of ANP in the ventricles [8].