Thus, development, and implementation of measures for early recognition and intervention, for treatment of firstepisode schizophrenia, for quality management, and for destigmatization will be in the focus of this last funding period before the GRNS

has to finance itself by other resources. These measures will comprise development, of manuals and brochures, and continued medical education measures, as well as the setting up of special competence centers for each of these topics. Nevertheless, an ongoing aim of the GRNS will still be to offer a research platform, particularly for clinical studies, in order to continue successful horizontal networking between the institutes of research. Maintenance Inhibitors,research,lifescience,medical and extension of the existing DNA and clinical data banks will be an important Inhibitors,research,lifescience,medical part, of this effort. The complexity of psychiatric disorders on the one hand, and the progressive specialization in research, especially when using complex biological methods, on the other hand, results in an Selleck YM155 increasing necessity for inter- and intradisciplinary collaboration organized into larger networks like the GRNS. Primarily, such a strategy seems promising to find answers to the urgent and complex questions regarding schizophrenia that are still unresolved. Notes This manuscript was written Inhibitors,research,lifescience,medical within the framework

of the German Research Network on Schizophrenia, which is funded by the German Federal Ministry for Education and Research BMBF (grants 01GI9932, 01GI0232, 01GI0532).
Attention deficit/hyperactivity disorder (ADHD) is the most common psychiatric Inhibitors,research,lifescience,medical disorder of childhood. In recent years there has been growing evidence that in many patients the disorder persists into adulthood. Meanwhile, adult ADHD has been

recognized in the literature as a valid clinical entity, affecting as many as 2% to 4% of adults.1 Symptomatology Inhibitors,research,lifescience,medical and diagnosis The core symptoms of ADHD are inattention, hyperactivity, and impulsivity.2 In most descriptions of ADHD in the 1980s and the early 1990s, it seemed that hyperactivity had to be present in every case as a striking symptom, but with growing knowledge of ADHD it became evident that not all patients-in particular girls-present hyperactivity. Since 1994, with the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM IV)3 three types of ADHD have been differentiated: Combined type (6 or more symptoms of Terminal deoxynucleotidyl transferase hyperactivity/impulsivity as well as of inattention); Inattentive type (6 or more symptoms of inattention); Hyperactive/impulsive type (6 or more symptoms of hyperactivity/impulsivity). A change in symptoms with increasing age is characteristic of ADHD. After puberty, hyperactivity often changes to inactivity; therefore, ADHD often is not accepted as a diagnosis in adults. Impulsivity normally lessens with age.