We believe that, with the further development of fundamental rese

We believe that, with the further development of fundamental research, we are looking forward to an increasing application prospect of tyrosine kinase inhibitors in clinical practice.

Acknowledgements The authors wish to thank Dr. Jan Zhang for his kind review of the manuscript, Dr. Feng Wei TPX-0005 cost for their expert technical assistance, Ms. Min-Yu Wang for her excellent laboratory management. This work was supported by a grant from the Ministry of Civil Affair, China ([2008]18). References 1. Masui H, Kawamoto T, Sato JD: Growth inhibition of human tumor cells in athymicmice by anti-Tideglusib cost Epidermal growth factor receptor monoclonal antibodies. Cancer Res 1984, 44: 1002–1007.PubMed 2. Yaish P, Gazit A, Gilon C: Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 1988, 242: 933–935.CrossRefPubMed 3. Gschwind A, Fischer OM, Ullrich A: The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004, 4: 361–370.CrossRefPubMed 4. Jose B: Epidermal growth factor receptor pathway inhibitors. Update on cancer therapeutics 2006, 1: 299–310.CrossRef 5. Fortunato C, Giampaolo T: EGFR Antagonists in

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