This fluorescent dye-labeled triglyceride could be used for particle localization in biological studies with the advantage among other fluorescent materials that any carrier that contains a triglyceride in its formulation
composition can be obtained and tracked. Acknowledgements The authors are grateful to CNPq/Brasília/KPT-8602 Brazil (LAF and RVC), CAPES (FF), and PIBIC/CNPq (JFB) for student scholarships and to Pronex and Pronem FAPERGS/CNPq, INCT-if CNPq/MCT, CNPq Brasil/Mexico, FAPERGS, CAPES, and Rede Nanobiotecnologia CAPES for the financial support. Electronic supplementary material Additional file 1: Supplementary Silmitasertib mouse material. Proton nuclear magnetic resonance of product 1. (DOCX 36 KB) References 1. Mora-Huertas CE, Fessi H, Elaissari A: Polymer-based nanocapsules for drug delivery. Int J Pharm 2010, 385:113–142.CrossRef 2. Bernardi A,
Braganhol E, Jager E, Figueiró F, Edelweiss MI, Pohlmann AR, Guterres SS, Battastini AMO: Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. Cancer Lett 2009, HKI-272 nmr 281:53–63.CrossRef 3. Mishra B, Patel BB, Tiwari S: Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine 2010, 6:9–24.CrossRef 4. Torrecilla D, Lozano MV, Lallana E, Neissa JI, Novoa-Carballal R, Vidal A, Fernandez-Megia E, Torres D, Rigueira R, Alonso MJ, Dominguez F: Anti-tumor efficacy of chitosan-g-poly(ethylene glycol) nanocapsules containing docetaxel: anti-TMEFF-2 functionalized nanocapsules vs. non-functionalized nanocapsules. Eur J Pharm Biopharm 2013, 83:330–337.CrossRef 5. Teixeira M, Alonso MI, Pinto MMM, Barbosa CM: Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone. Eur J
Pharm Biopharm 2005, 59:491–500.CrossRef 6. Cruz L, Soares LU, Dalla-Costa T, Mezzalira G, da Silveira NP, Guterres SS, Pohlmann AR: Diffusion and mathematical modeling of release profiles from nanocarriers. Int J Pharm 2006, 313:198–205.CrossRef 7. Jager E, Venturini CG, Poletto Carteolol HCl FS, Colomé LM, Pohlmann JPU, Bernardi A, Battastini AMO, Guterres SS, Pohlmann AR: Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area. J Biomed Nanotechnol 2009, 5:130–140.CrossRef 8. Venturini CG, Jager E, Oliveira CP, Bernardi A, Battastini AMO, Guterres SS, Pohlmann AR: Formulation of lipid core nanocapsules. Colloids Surf A 2011, 375:200–208.CrossRef 9. Poletto FS, Oliveira CP, Wender H, Regent D, Teixeira SR, Guterres SS, Rossi Bergmann B, Pohlmann AR: How sorbitan monostearate can increase drug-loading capacity of lipid-core polymeric nanocapsules. J Nanosci Nanotechnol 2014. in press 10. Gumbleton ME, Stephens DJ: Coming out of the dark: the evolving role of fluorescence imaging in drug delivery research. Adv Drug Deliv Rev 2005,57(1):5–15.CrossRef 11.