Conclusion. This study identified
new correlates of moderate-severe hip pain after primary or revision THA, a much-feared outcome of hip arthroplasty. Patients with these comorbidities should be informed regarding the risk of moderate-severe index hip pain, so that they can have a fully informed consent and realistic expectations.”
“Direct and reverse martensitic transformations have been studied in Mn50Ni40In10 ribbons by means of magnetization and electrical resistivity measurements. The alloy is L2(1)-type single-phase austenite, which transforms into a 14M monoclinic martensite. The martensitic transformation is accompanied by a large change in the electrical resistivity. The field dependence of characteristic transformation temperatures is reported. A field-induced reverse martensitic transformation with large hysteretic CH5183284 manufacturer losses was observed. The reversibility of magnetization isotherms in the temperature interval where direct martensitic transformation occurs is also reported.
(c) 2009 American Institute of Physics. [DOI: 10.1063/1.3078413]“
“Tulathromycin is a triamilide antibiotic that maintains therapeutic concentrations for an extended period of time. The drug is approved for the treatment of respiratory disease in cattle and swine and is occasionally used in goats. To investigate the pharmacokinetics of tulathromycin in meat goats, 10 healthy Boer goats were administered a single 2.5 mg/kg subcutaneous dose of tulathromycin. Plasma concentrations were measured by ultra-high pressure liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detection. Plasma maximal drug concentration
(C(max)) was 633 +/- 300 ng/ml (0.40 +/- GSK1904529A chemical structure 0.26 h post-subcutaneous injection). The half-life of tulathromycin in goats was 110 +/- 19.9 h. Tulathromycin was rapidly absorbed and distributed widely after subcutaneous injection 33 +/- 6 L/kg. The mean AUC of the group was 12,500 +/- 2020 h ng/mL for plasma. In this study, it was determined that the pharmacokinetics of tulathromycin after a single 2.5 mg/kg SC injection in goats were very similar to what has been previously reported in cattle. (C) 2010 Elsevier Ltd. All rights reserved.”
“Objective. Compare the efficacy and tolerability of AZD7762 mw the dual-opioid, Q8003 (R) (morphine/oxycodone combination) 12 mg/8 mg to morphine 12 mg or oxycodone 8 mg in subjects following bunionectomy surgery.
Design. This was a randomized, double-blind study.
Setting. Hospitalized patients.
Patients. Healthy men or women aged >= 18 years with moderate or severe pain (score >= 2 on a 4-point Likert scale) and >= 4 on the 11-point numerical pain rating scale following surgery.
Interventions. Study medication was initiated after surgery and was given for 48 hours.
Outcomes. The primary efficacy variable was mean sum of the pain intensity difference (SPID) scores from the postsurgical baseline.
Results. Five hundred twenty-two subjects were randomized; 31 (5.