Consideration of diastolic function should be included in the management of patients with atherosclerotic renovascular disease. (J Vase Surg 2011;54:1720-6.)”
“Schwann cells (SCs) express distinct sensory and motor phenotypes, which are associated with modality-specific promotion of axon growth. Here we compared cell proliferation and migration of primary cultured sensory and motor SCs and determined the mRNA Bromosporine mw expression of several genes, nap1l1, dok4, lpp, mmp-9 and l1cam, in two phenotypes of SCs. The results showed that the rate of cell proliferation or migration was higher in sensory SCs than in motor SCs, and the five proliferation or migration-related
genes also had higher expression in sensory SCs than in motor SCs. These findings may provide a basis for deeply studying
the biological differences between sensory and motor SCs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Chronic pain is a classic example of gene x environment interaction: inflammatory and/or nerve injuries are known or suspected to be the etiology of most chronic pain syndromes, but only a small minority of those subjected to such injuries actually develop chronic pain. Once chronic pain has developed, pain severity and analgesic response are RepSox research buy also highly variable among individuals. Although animal genetics studies have been ongoing for over two decades, only PF477736 molecular weight recently have comprehensive human twin studies and large-scale association studies been performed. Here, I review recent and accelerating progress in, and continuing challenges to, the identification of genes contributing to such variability. Success in this endeavor will hopefully lead to both better management of pain using currently available therapies and the development and/or prioritizing of new ones.”
“A wealth of studies has demonstrated that patients with schizophrenia are impaired in “”theory of mind”" (ToM). Here,
we used a novel five-factor model of the Positive and Negative Syndrome Scale(PANSS) to test the hypothesis that selectivity of ToM deficits in schizophrenia depends on the predominating symptoms. We predicted that ToM impairments would be non-selective in patients with pronounced negative (NF) or disorganized symptoms (DF), whereas selective ToM impairment would Occur in patients with predominant positive symptoms (PF). We recruited 50 patients diagnosed with schizophrenia or schizoaffective disorder and examined premorbid intelligence, executive functioning, ToM and psychopathology in comparison to a group of 29 healthy controls. Compared with healthy controls, patients performed more poorly on tasks involving executive functioning and ToM abilities. Using a novel PANSS five-factor model, we found a significant association of ToM deficits with the “”disorganization”" factor.