“Aim: To develop a patient-based Simple Clinical Colitis Activity Index (P-SCCAI) of ulcerative colitis (UC) activity and to
compare it with the clinician-based SCCAI, C-reactive protein (CRP) and Physician’s Global Assessment (PGA) of UC activity. PD-1/PD-L1 Inhibitor 3 nmr Monitoring UC activity may give patients disease control and prevent unnecessary examinations.
Methods: Consecutive UC patients randomly completed the P-SCCAI either before or after consultation. Gastroenterologists assessed patients’ UC activity on the same day. Overall agreement between SCCAI and P-SCCAI was calculated with Spearman’s Rho and Mann Whitney U test. Agreement regarding active disease versus remission and agreement at domain level were calculated by percent agreement and kappa (lc).
Results: 149 (response rate 84.7%) UC patients participated. P-SCCAI and SCCAI showed a large correlation (rs= 0.79). The medians (IQR) of the P-SCCAI (3.78;0-15) tended to be higher than those of the SCCAI (2.86;0-13), although this difference did not reach statistical significance (z= 1.711 p =0.088). In 77% of the cases the difference
between clinicians and patients’ scores was not clinically different (i.e. 2). Percentage agreement between clinicians and patients, judging UC as active or in remission, was 87%, rs = 0.66, tc=0.66, indicating a substantial agreement. In general patients tended to report more physical symptoms than clinicians. C-Reactive protein (CRP) was found to have a significant association with both P-SCCAI and SCCAI (K=0.32, K=0.39 respectively) as was PGA (K=0.73 for both indices).
Conclusions: The P-SCCAI is a promising tool given its substantial agreement with the SCCAI 5-Fluoracil and its feasibility. Therefore, P-SCCAI
can complement SCCAI in clinical care and research. (C) 2012 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Objective: The objective of this study was to measure distress at three points during the course of chemotherapy: beginning, middle, and the last day of therapy in a private cancer center in Brazil.
Methods: One hundred patients were assessed at three points during chemotherapy using the Distress Thermometer (DT) and the Hospital Anxiety selleckchem and Depression Scale (HADS). The data were analyzed with the support of SPSS 15.0 software.
Results: At the beginning of chemotherapy, patients mean scores were distress (82%), anxiety (78%) and depression (55%). In the middle of treatment, the percentages of distress, anxiety and depression decreased to 36.4, 25 and 25.3%, respectively. On the last day, the levels were 18.2% for distress and 14.3% for both anxiety and depression.
Conclusion: Distress is highest in these patients at the beginning of chemotherapy, suggesting that evaluation of patients for psychosocial needs is important. Screening with a simple rapid instrument such as the DT is feasible and useful. Copyright (C) 2010 John Wiley & Sons, Ltd.”
“Introduction and objectives.